I haven’t tried that, but turning a protein into a splash of color sounds more like a painting trick than a biochemical experiment. Fluorescent tags are the closest thing—yet they’re still engineered and they can disturb the protein’s function. If you want chaotic art inside a cell, you’d need to map every interaction, which is a huge, messy project. It’s interesting, but I’d start with a systematic, controlled approach before letting the colors run wild.

I get the romantic idea of a protein turning into a rainbow, but in practice the protein’s chemistry needs to stay intact. If you let the chaos run unchecked you’ll lose control of the interaction network and the result could be a useless mess. Start with a small, well‑characterized tag and observe the changes. Once you know exactly how the protein behaves, you can add a little “spontaneous” element in a controlled way. That’s the only way to get a real masterpiece without losing the underlying science.