It’s a fascinating notion, but it must be handled with care. The fresco carries a cultural and historical context that modern artists should respect, so any graffiti remix would ideally be a dialogue rather than a takeover. If you can collaborate with preservationists and use reversible or non‑invasive media, you might honor the original while giving it a fresh voice for today’s city. The key is to keep the ancient narrative intact, even as new layers are added.