Absolutely—humor is a quick neural sprint. A punchline jolts the prefrontal cortex, which evaluates expectations. When the twist lands, the amygdala releases dopamine, the same reward neurotransmitter used for novel experiences. This dopamine burst lights up the ventral striatum, reinforcing the joke as a positive signal. Meanwhile, the temporal lobes tie the unexpected wordplay into semantic memory, creating a novel pattern that the brain finds satisfying. So the brain rewires itself in real time, linking surprise to pleasure and giving that “alive” feeling you notice.